|
KMID : 0895820200300030057
|
|
Journal of Oriental Rehabilitation Medicine
2020 Volume.30 No. 3 p.57 ~ p.69
|
|
|
The Inhibitory Effect of ChondroT on Indomethacin-Induced Gastric Mucosal Injury in Rats
|
|
Kim Joo-Il
Kim Sun-Gil
Kim Ji-Hoon
Yoon Chan-Suk
Choi Ji-Min
Choi Ji-Min
Choi Chan-Hun
Kim Seon-Jong
|
|
|
Abstract
|
|
|
Objectives : The aim of this study was to investigate the inhibitory effect of ChondroT in indomethacin-induced gastric mucosal injury rat model.
Methods : Sprague-Dawley rats were randomly assigned to intact, control Joins, Celebrex, ChondroT50 and ChondroT200. Indomethacin (25 mg/kg) was used to induce damage to the gastric mucosal injury. ChondroT was administered by orally to inhibit the indomethacin-induced gastric mucosal injury. At the end of the experiment, pH level in stomach, stomach contents volume, tumor necrosis factor-α (TNF-α) level, interleukin-1β (IL-1β) level, prostaglandin E2 (PGE2) level, myeloperoxidase (MPO) activity, erythrocytes, and thrombocytes were measured. Ophthalmologic and histopathological examination was also analyzed.
Results : pH level in stomach and Stomach contents volume had no difference between Control, PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group. TNF-α level was decreased in PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group and there were no significant difference. IL-1β level was decreased in PC-Joins group and ChondroT200 group compared to control group. PGE2 level had no significant difference between Control, PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group. MPO level and complete blood count level were decreased in PC-Joins, PC-Cele, ChondroT50 and ChondroT200. Symptom score of ophthalmologic examination was decreased in ChondroT50 and ChondroT200 group compared to control group.
Conclusion : Based on these results, It could be suggested that ChondroT was effective in reducing damage to the gastric mucosal injury. And further study is needed to conduct a rigorous clinical research.
|
|
|
KEYWORD
|
|
|
ChondroT, Osteoarthritis, Gastric disease, Indomethacin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|